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Bisoren 10mg Tablet 1 Strip
Bisoren is used to treat:
✔ Hypertension (High Blood Pressure)
✔ Angina (Chest Pain)
✔ Moderate to Severe Heart Failure
🚫 Not recommended for emergency treatment of hypertensive crises.
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✅ Description:
Bisoren (Bisoprolol) is a highly selective β1-blocker used for hypertension, angina, and heart failure. It offers once-daily dosing with minimal fluctuations in drug levels.
Bisoprolol is the most selective β1-blocker available. It selectively blocks β1-adrenergic receptors in the heart and vascular smooth muscle, reducing:
- Heart rate
- Cardiac output
- Blood pressure
✔ Unlike non-selective beta-blockers, Bisoprolol does not negatively affect lipid metabolism (cholesterol levels).
✔ It has a long half-life (10-12 hours), allowing for once-daily dosing with minimal fluctuations in blood levels.
Pharmacokinetics
✔ Absorption: Rapid absorption (>90%) from the GI tract, bioavailability 88%.
✔ Metabolism: Mainly metabolized in the liver (CYP3A4 pathway), but does not require conjugation.
✔ Elimination: Balanced between renal excretion (50%) and hepatic metabolism (50%).
✔ Half-life: 10–12 hours, supporting once-daily dosing.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration of Bisoren 10
✔ Adults (Hypertension & Angina):
- Start with 5 mg once daily (alone or with a diuretic).
- If needed, increase to 10 mg once daily, then to 20 mg once daily.
- Maximum effective dose: 20 mg/day.
- Titrate dose every 2 weeks if needed.
✔ Patients with Renal or Hepatic Impairment:
- Start with 5 mg once daily.
- Use caution with dose increases (risk of drug accumulation).
- Not removed by dialysis—no need for replacement dosing.
✔ Elderly Patients:
- Usually no dose adjustment needed unless severe renal or hepatic dysfunction is present.
🚫 Children:
- Safety and effectiveness not established—not recommended.
✔️ Side Effects of Bisoren 10
✔ Common Side Effects:
- Fatigue & Dizziness
- Headache
- Digestive Issues – Nausea, vomiting, diarrhea, constipation, abdominal pain
- Cold or numb hands and feet
- Muscle weakness or cramps
✔ Less Common but Serious Side Effects:
- Slow heart rate (bradycardia)
- Breathing difficulties (bronchospasm) in asthma or COPD patients
- Severe hypotension (low blood pressure)
✔️ Avoid combining Bisoren with:
- Other β-blockers – Risk of excessive bradycardia or hypotension.
- Catecholamine-depleting drugs (e.g., reserpine, guanethidine) – May lead to excessive suppression of sympathetic activity.
- Centrally Acting Antihypertensives (e.g., Clonidine) – Can cause rebound hypertension when discontinued. If used together:
- Taper off β-blocker first, then stop clonidine a few days later.
- Antiarrhythmic Agents (e.g., Verapamil, Diltiazem, Disopyramide) – Can cause bradycardia, conduction issues, severe hypotension, or heart failure.
- Calcium Channel Blockers (e.g., Amlodipine, Diltiazem, Verapamil) – Risk of excessive heart rate slowing and low blood pressure.
✔️ Do NOT use Bisoren if you have:
- Cardiogenic shock
- Overt heart failure
- Severe A-V block (2nd or 3rd degree)
- Severe sinus bradycardia
- Right ventricular failure due to pulmonary hypertension
✔️ Benefits: Bisoren 10
✔ Effective in reducing heart rate and blood pressure
✔ Less effect on lipid metabolism compared to other beta-blockers
✔ Requires careful dose adjustments in kidney/liver disease
✔ Avoid abrupt discontinuation—always taper off under medical supervision
✔️ Use in Pregnancy & Lactation
⚠ Pregnancy:
- Bisoprolol was not teratogenic in animal studies, but can be toxic at high doses.
- Limited human data – should only be used if benefits outweigh risks.
⚠ Lactation:
- Small amounts of Bisoprolol are excreted in animal milk—unknown for humans.
- If essential for the mother, breastfeeding should be stopped.
✔️ Use Bisoren with caution in:
✔ Impaired Kidney or Liver Function – May require dose adjustments.
✔ History of Severe Allergic Reactions – May have reduced response to epinephrine during anaphylaxis.
✔ Asthma or COPD – Risk of bronchospasm; use with caution.
✔ Diabetes – Can mask symptoms of low blood sugar (hypoglycemia).
✔ Thyroid Disorders – Can mask symptoms of hyperthyroidism.
✔ Heart Block or Low Heart Rate – Risk of worsening bradycardia.
✔️ Storage:
✔ Store in a cool, dry place (below 25°C).
✔ Keep away from heat, light, and moisture.
✔ Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
