Bisoren is used to treat:
✔ Hypertension (High Blood Pressure)
✔ Angina (Chest Pain)
✔ Moderate to Severe Heart Failure
🚫 Not recommended for emergency treatment of hypertensive crises.
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Bisoren (Bisoprolol) is a highly selective β1-blocker used for hypertension, angina, and heart failure. It offers once-daily dosing with minimal fluctuations in drug levels.
Bisoprolol is the most selective β1-blocker available. It selectively blocks β1-adrenergic receptors in the heart and vascular smooth muscle, reducing:
Pharmacokinetics
✔ Absorption: Rapid absorption (>90%) from the GI tract, bioavailability 88%.
✔ Metabolism: Mainly metabolized in the liver (CYP3A4 pathway), but does not require conjugation.
✔ Elimination: Balanced between renal excretion (50%) and hepatic metabolism (50%).
✔ Half-life: 10–12 hours, supporting once-daily dosing.
✔ Adults (Hypertension & Angina):
✔ Patients with Renal or Hepatic Impairment:
✔ Elderly Patients:
🚫 Children:
✔ Common Side Effects:
✔ Less Common but Serious Side Effects:
✔ Effective in reducing heart rate and blood pressure
✔ Less effect on lipid metabolism compared to other beta-blockers
✔ Requires careful dose adjustments in kidney/liver disease
✔ Avoid abrupt discontinuation—always taper off under medical supervision
⚠ Pregnancy:
⚠ Lactation:
✔ Impaired Kidney or Liver Function – May require dose adjustments.
✔ History of Severe Allergic Reactions – May have reduced response to epinephrine during anaphylaxis.
✔ Asthma or COPD – Risk of bronchospasm; use with caution.
✔ Diabetes – Can mask symptoms of low blood sugar (hypoglycemia).
✔ Thyroid Disorders – Can mask symptoms of hyperthyroidism.
✔ Heart Block or Low Heart Rate – Risk of worsening bradycardia.
✔ Store in a cool, dry place (below 25°C).
✔ Keep away from heat, light, and moisture.
✔ Keep out of reach of children.
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